Polyclonal F(ab’)(2) fragments of equine antibodies raised against the spike protein neutralize SARS-CoV-2 variants with high potency

We used the recombinant trimeric spike (S) glycoprotein in the prefusion conformation to immunize horses for the production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by ELISA were above 1:10(6), and the neutralizing antibody titer against authentic virus (WT) was 1:...

Descripción completa

Detalles Bibliográficos
Autores principales: Cunha, Luis Eduardo R., Stolet, Adilson A., Strauch, Marcelo A., Pereira, Victor A.R., Dumard, Carlos H., Gomes, Andre M.O., Monteiro, Fábio L., Higa, Luiza M., Souza, Patrícia N.C., Fonseca, Juliana G., Pontes, Francisco E., Meirelles, Leonardo G.R., Albuquerque, José W.M., Sacramento, Carolina Q., Fintelman-Rodrigues, Natalia, Lima, Tulio M., Alvim, Renata G.F., Marsili, Federico F., Caldeira, Marcella Moreira, Zingali, Russolina B., de Oliveira, Guilherme A.P., Souza, Thiago M.L., Silva, Alexandre S., Muller, Rodrigo, Rodrigues, Daniela del Rosário Flores, Jesus da Costa, Luciana, Alves, Arthur Daniel R., Pinto, Marcelo Alves, Oliveira, Andréa C., Guedes, Herbert L.M., Tanuri, Amilcar, Castilho, Leda R., Silva, Jerson L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539203/
https://www.ncbi.nlm.nih.gov/pubmed/34723156
http://dx.doi.org/10.1016/j.isci.2021.103315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539203/
https://www.ncbi.nlm.nih.gov/pubmed/34723156
http://dx.doi.org/10.1016/j.isci.2021.103315

Ejemplares similares