Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists

An expansion of the structure–activity relationship study of CXCR4 antagonists led to the synthesis of a series of isoquinolines, bearing a tetrahydroquinoline or a 3-methylpyridinyl moiety as head group. All compounds were investigated for CXCR4 affinity and antagonism in competition binding and ca...

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Detalles Bibliográficos
Autores principales: Shad, Mastaneh Safarnejad, Claes, Sandra, Goffin, Eline, Van Loy, Tom, Schols, Dominique, De Jonghe, Steven, Dehaen, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539250/
https://www.ncbi.nlm.nih.gov/pubmed/34684878
http://dx.doi.org/10.3390/molecules26206297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539250/
https://www.ncbi.nlm.nih.gov/pubmed/34684878
http://dx.doi.org/10.3390/molecules26206297

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