Cargando…

Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and Invasion

Type 1 diabetes mellitus (T1DM) is associated with reduced fetal growth in early pregnancy, but a contributing role of the placenta has remained elusive. Thus, we investigated whether T1DM alters placental development in the first trimester. Using a protein array, the level of 60 cell-cycle-related...

Descripción completa

Detalles Bibliográficos
Autores principales:	Majali-Martinez, Alejandro, Weiss-Fuchs, Ursula, Miedl, Heidi, Forstner, Desiree, Bandres-Meriz, Julia, Hoch, Denise, Djelmis, Josip, Ivanisevic, Marina, Hiden, Ursula, Gauster, Martin, Desoye, Gernot
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539403/ https://www.ncbi.nlm.nih.gov/pubmed/34681648 http://dx.doi.org/10.3390/ijms222010989

Ejemplares similares

Maternal C-Peptide and Insulin Sensitivity, but Not BMI, Associate with Fatty Acids in the First Trimester of Pregnancy
por: Bandres-Meriz, Julia, et al.
Publicado: (2021)

Expression of matrix metalloproteinase 12 is highly specific for non-proliferating invasive trophoblasts in the first trimester and temporally regulated by oxygen-dependent mechanisms including HIF-1A
por: Hiden, Ursula, et al.
Publicado: (2017)

Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy
por: Bandres-Meriz, Julia, et al.
Publicado: (2023)

The first trimester human trophoblast cell line ACH-3P: A novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations – TNF-α stimulates MMP15 expression
por: Hiden, Ursula, et al.
Publicado: (2007)

Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B
por: Majali-Martinez, Alejandro, et al.
Publicado: (2017)

Downregulation of p53 drives autophagy during human trophoblast differentiation
por: Gauster, Martin, et al.
Publicado: (2017)

Flow-through isolation of human first trimester umbilical cord endothelial cells
por: Gruber, Michael, et al.
Publicado: (2021)

Matrix metalloproteinase 15 plays a pivotal role in human first trimester cytotrophoblast invasion and is not altered by maternal obesity
por: Majali‐Martinez, Alejandro, et al.
Publicado: (2020)

Pigment epithelium-derived factor (PEDF): a novel trophoblast-derived factor limiting feto-placental angiogenesis in late pregnancy
por: Loegl, Jelena, et al.
Publicado: (2016)

Maternal Obesity Affects the Glucose-Insulin Axis During the First Trimester of Human Pregnancy
por: Bandres-Meriz, Julia, et al.
Publicado: (2020)

The Human Placental Sexome Differs between Trophoblast Epithelium and Villous Vessel Endothelium
por: Cvitic, Silvija, et al.
Publicado: (2013)

Glucose, Insulin and Oxygen Modulate Expression of Serotonin-Regulating Genes in Human First-Trimester Trophoblast Cell Line ACH-3P
por: Perić, Maja, et al.
Publicado: (2023)

Glucose, Insulin, and Oxygen Interplay in Placental Hypervascularisation in Diabetes Mellitus
por: Cvitic, Silvija, et al.
Publicado: (2014)

Changes in Maternal Platelet Physiology during Gestation and Their Interaction with Trophoblasts
por: Forstner, Désirée, et al.
Publicado: (2021)

Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1
por: Hoch, Denise, et al.
Publicado: (2020)

Dysregulation of Placental Endothelial Lipase in Obese Women With Gestational Diabetes Mellitus
por: Gauster, Martin, et al.
Publicado: (2011)

Variable promoter methylation contributes to differential expression of key genes in human placenta-derived venous and arterial endothelial cells
por: Joo, Jihoon E, et al.
Publicado: (2013)

Maternal Platelets—Friend or Foe of the Human Placenta?
por: Moser, Gerit, et al.
Publicado: (2019)

Metalloprotease Dependent Release of Placenta Derived Fractalkine
por: Siwetz, Monika, et al.
Publicado: (2014)

Transient Hyperglycemia and Hypoxia Induce Memory Effects in AngiomiR Expression Profiles of Feto-Placental Endothelial Cells
por: Strutz, Jasmin, et al.
Publicado: (2021)

Lower HLA-G levels in extravillous trophoblasts of human term placenta in gestational diabetes mellitus than in normal controls
por: Knabl, Julia, et al.
Publicado: (2022)

Human Milk Oligosaccharides in Cord Blood Are Altered in Gestational Diabetes and Stimulate Feto-Placental Angiogenesis In Vitro
por: Hoch, Denise, et al.
Publicado: (2021)

Candesartan Does Not Activate PPARγ and Its Target Genes in Early Gestation Trophoblasts
por: Neuper, Lena, et al.
Publicado: (2022)

Placental CX3CL1 is Deregulated by Angiotensin II and Contributes to a Pro-Inflammatory Trophoblast-Monocyte Interaction
por: Nonn, Olivia, et al.
Publicado: (2019)

Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta
por: Lee, Cheryl Q. E., et al.
Publicado: (2018)

Human Placental Hofbauer Cells Maintain an Anti-inflammatory M2 Phenotype despite the Presence of Gestational Diabetes Mellitus
por: Schliefsteiner, Carolin, et al.
Publicado: (2017)

Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
por: Rossmann, C., et al.
Publicado: (2014)

Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts
por: Brugger, Beatrice Anna, et al.
Publicado: (2023)

Placental Endocrine Activity: Adaptation and Disruption of Maternal Glucose Metabolism in Pregnancy and the Influence of Fetal Sex
por: Stern, Christina, et al.
Publicado: (2021)

Serotonin system in the human placenta – the knowns and unknowns
por: Perić, Maja, et al.
Publicado: (2022)

Go with the Flow—Trophoblasts in Flow Culture
por: Brugger, Beatrice A., et al.
Publicado: (2020)

Function of Survivin in Trophoblastic Cells of the Placenta
por: Muschol-Steinmetz, Cornelia, et al.
Publicado: (2013)

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast
por: Lee, Cheryl Q.E., et al.
Publicado: (2016)

Placental DAPK1 and autophagy marker LC3B-II are dysregulated by TNF-α in a gestational age-dependent manner
por: Prokesch, Andreas, et al.
Publicado: (2017)

Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2
por: Tapia, Alejandro, et al.
Publicado: (2008)

Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
por: Horvatiček, Marina, et al.
Publicado: (2022)

Trophoblast cells of ruminant placentas - A minireview
por: Igwebuike, U M
Publicado: (2004)

Effect of imiquimod on cytokine induction in first trimester trophoblasts.
por: Manlove-Simmons, J M, et al.
Publicado: (2000)

CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta
por: Forstner, Désirée, et al.
Publicado: (2023)

Early human trophoblast development: from morphology to function
por: Gauster, Martin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vuukctrgl6kit7o18snletc1p8