Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons

As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biological processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at high levels and is involved in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD) and Pa...

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Detalles Bibliográficos
Autores principales: Jun, Joonhong, Baek, Jihyun, Yang, Songyi, Moon, Hyungwoo, Kim, Hyejin, Cho, Hyunwook, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539420/
https://www.ncbi.nlm.nih.gov/pubmed/34681742
http://dx.doi.org/10.3390/ijms222011084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539420/
https://www.ncbi.nlm.nih.gov/pubmed/34681742
http://dx.doi.org/10.3390/ijms222011084

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