Cargando…

Inflammation Induces Changes in the Functional Expression of P-gp, BCRP, and MRP2: An Overview of Different Models and Consequences for Drug Disposition

The ATP-binding cassette (ABC) transporters play a key role in drug pharmacokinetics. These membrane transporters expressed within physiological barriers can be a source of pharmacokinetic variability. Changes in ABC transporter expression and functionality may consequently affect the disposition of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saib, Sonia, Delavenne, Xavier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539483/ https://www.ncbi.nlm.nih.gov/pubmed/34683838 http://dx.doi.org/10.3390/pharmaceutics13101544

Ejemplares similares

Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP
por: Gameiro, Mariline, et al.
Publicado: (2017)

Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines
por: Feinshtein, Valeria, et al.
Publicado: (2013)

The Effect of Albumin on MRP2 and BCRP in the Vesicular Transport Assay
por: Deng, Feng, et al.
Publicado: (2016)

Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators
por: Dei, Silvia, et al.
Publicado: (2019)

Characterization of SN38-resistant T47D breast cancer cell sublines overexpressing BCRP, MRP1, MRP2, MRP3, and MRP4
por: Lee, Hee-Jeong, et al.
Publicado: (2022)

Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells
por: Pawłowski, Karol M, et al.
Publicado: (2013)

An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR(–) Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown
por: Yang, Kyunghee, et al.
Publicado: (2014)

Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy
por: Szatmári, Péter, et al.
Publicado: (2023)

Folium Sennae Increased the Bioavailability of Methotrexate through Modulation on MRP 2 and BCRP
por: Yu, Chung-Ping, et al.
Publicado: (2021)

Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion
por: Ding, Xuedong, et al.
Publicado: (2019)

Dual Inhibition of P-gp and BCRP Improves Oral Topotecan Bioavailability in Rodents
por: Lee, Jaeok, et al.
Publicado: (2021)

Polarized macrophage subsets differentially express the drug efflux transporters MRP1 and BCRP, resulting in altered HIV production
por: He, Hui, et al.
Publicado: (2018)

Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells
por: Schexnayder, Chandler, et al.
Publicado: (2015)

Drug-disease interaction: Clinical consequences of inflammation on drugs action and disposition
por: Abdallah, Yasmeen El Hajj, et al.
Publicado: (2023)

(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood–brain barrier, and not by MRP1 and BCRP
por: Römermann, Kerstin, et al.
Publicado: (2013)

ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice
por: Brzozowska, Natalia, et al.
Publicado: (2016)

Allicin affects the pharmacokinetics of sulfadiazine and florfenicol by downregulating the expression of jejunum P-gp and BCRP in broilers
por: Wang, Xiaoming, et al.
Publicado: (2022)

Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2
por: Xu, Peng, et al.
Publicado: (2018)

The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition
por: Yu, Fangjun, et al.
Publicado: (2019)

Expression of Drug Pump Protein MRP2 in Lipopolysaccharide-Treated Rats and its Impact on the Disposition of Acetaminophen
por: Hassany, Mitra, et al.
Publicado: (2011)

Inhibitory Effects of Quercetin and Its Main Methyl, Sulfate, and Glucuronic Acid Conjugates on Cytochrome P450 Enzymes, and on OATP, BCRP and MRP2 Transporters
por: Mohos, Violetta, et al.
Publicado: (2020)

Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning
por: Montanari, Floriane, et al.
Publicado: (2016)

CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer
por: Chen, Nanzheng, et al.
Publicado: (2019)

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
por: Zhang, Lei, et al.
Publicado: (2020)

Opioids and the Blood-Brain Barrier: A Dynamic Interaction with  Consequences on Drug Disposition in Brain
por: Chaves, Catarina, et al.
Publicado: (2017)

Serum MRP8/MRP14 as a biomarker for inflammation in autoimmune arthritis
por: De Rycke, L, et al.
Publicado: (2004)

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice
por: Hernández-Lozano, Irene, et al.
Publicado: (2021)

Overexpression of MRP1/ABCC1, Survivin and BCRP/ABCC2 Predicts the Resistance of Diffuse Large B-Cell Lymphoma to R-CHOP Treatment
por: Mandić, Danijela, et al.
Publicado: (2023)

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P‐Glycoprotein (P‐gp) and Breast Cancer Resistance Protein (BCRP)
por: Schwarz, Theresa, et al.
Publicado: (2016)

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models
por: Boumendjel, Ahcene, et al.
Publicado: (2009)

BCRP and P-gp relay overexpression in triple negative basal-like breast cancer cell line: a prospective role in resistance to Olaparib
por: Dufour, Robin, et al.
Publicado: (2015)

Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5
por: Sachs, Julia, et al.
Publicado: (2019)

Effect of enzalutamide on PK of P‐gp and BCRP substrates in cancer patients: CYP450 induction may not always predict overall effect on transporters
por: Poondru, Srinivasu, et al.
Publicado: (2022)

Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP/P-gp
por: Zhao, Tingting, et al.
Publicado: (2022)

Dual-phase (99m)Tc-MIBI imaging and the expressions of P-gp, GST-π, and MRP1 in hyperparathyroidism
por: Xue, Jianjun, et al.
Publicado: (2017)

Evaluation of drug interaction potential of zanubrutinib with cocktail probes representative of CYP3A4, CYP2C9, CYP2C19, P‐gp and BCRP
por: Ou, Ying C., et al.
Publicado: (2021)

Virtual Screening of DrugBank Reveals Two Drugs as New BCRP Inhibitors
por: Montanari, Floriane, et al.
Publicado: (2016)

Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication
por: Dambra, Richard, et al.
Publicado: (2022)

Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors
por: Lemos, C, et al.
Publicado: (2008)

Sex Differences in Drug Disposition
por: Soldin, Offie P., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_o6jpoh2mb9bad91nrjlrcsv7h2