Cargando…

Copper-Containing Nanoparticles and Organic Complexes: Metal Reduction Triggers Rapid Cell Death via Oxidative Burst

Copper-containing agents are promising antitumor pharmaceuticals due to the ability of the metal ion to react with biomolecules. In the current study, we demonstrate that inorganic Cu(2+) in the form of oxide nanoparticles (NPs) or salts, as well as Cu ions in the context of organic complexes (oxida...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsymbal, Sergey A., Moiseeva, Anna A., Agadzhanian, Nikol A., Efimova, Svetlana S., Markova, Alina A., Guk, Dmitry A., Krasnovskaya, Olga O., Alpatova, Victoria M., Zaitsev, Andrei V., Shibaeva, Anna V., Tatarskiy, Victor V., Dukhinova, Marina S., Ol’shevskaya, Valentina A., Ostroumova, Olga S., Beloglazkina, Elena K., Shtil, Alexander A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539714/ https://www.ncbi.nlm.nih.gov/pubmed/34681725 http://dx.doi.org/10.3390/ijms222011065

Ejemplares similares

Multicomponent Molecular Systems Based on Porphyrins, 1,3,5-Triazine and Carboranes: Synthesis and Characterization
por: Alpatova, Victoria M., et al.
Publicado: (2022)

Fluorinated maleimide-substituted porphyrins and chlorins: synthesis and characterization
por: Ol’shevskaya, Valentina A, et al.
Publicado: (2019)

Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics
por: Tsymbal, Sergey, et al.
Publicado: (2022)

Novel Photosensitizers Trigger Rapid Death of Malignant Human Cells and Rodent Tumor Transplants via Lipid Photodamage and Membrane Permeabilization
por: Moisenovich, Mikhail M., et al.
Publicado: (2010)

Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes
por: Kokinos, Elena K., et al.
Publicado: (2023)

Synthesis, Characterization and DFT Study of a New Family of High-Energy Compounds Based on s-Triazine, Carborane and Tetrazoles
por: Makarenkov, Anton V., et al.
Publicado: (2022)

Copper Coordination Compounds as Biologically Active Agents
por: Krasnovskaya, Olga, et al.
Publicado: (2020)

Recent Advances in Light-Controlled Activation of Pt(IV) Prodrugs
por: Spector, Daniil, et al.
Publicado: (2022)

Tacrine-Based Hybrids: Past, Present, and Future
por: Bubley, Anna, et al.
Publicado: (2023)

Fengycin induces ion channels in lipid bilayers mimicking target fungal cell membranes
por: Zakharova, Anastasiia A., et al.
Publicado: (2019)

Probing Amphotericin B Single Channel Activity by Membrane Dipole Modifiers
por: Ostroumova, Olga S., et al.
Publicado: (2012)

Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host
por: Efimova, Svetlana S., et al.
Publicado: (2020)

Phosphodiesterase Type 5 Inhibitors Greatly Affect Physicochemical Properties of Model Lipid Membranes
por: Zakharova, Anastasiia A., et al.
Publicado: (2021)

Lipid Microenvironment Modulates the Pore-Forming Ability of Polymyxin B
por: Zakharova, Anastasiia A., et al.
Publicado: (2022)

New Titanocene (IV) Dicarboxylates with Potential Cytotoxicity: Synthesis, Structure, Stability and Electrochemistry
por: Guk, Dmitry A., et al.
Publicado: (2023)

Triggering the Amphotericin B Pore-Forming Activity by Phytochemicals
por: Efimova, Svetlana S., et al.
Publicado: (2023)

Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics
por: Zakharova, Anastasiia A., et al.
Publicado: (2018)

PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
por: Soshnikova, N.V., et al.
Publicado: (2021)

Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions
por: Dukhinova, Marina S., et al.
Publicado: (2019)

Is the Membrane Lipid Matrix a Key Target for Action of Pharmacologically Active Plant Saponins?
por: Efimova, Svetlana S., et al.
Publicado: (2021)

Modulation of the Dipole Potential of Model Lipid Membranes with Phytochemicals: Molecular Mechanisms, Structure–Activity Relationships, and Implications in Reconstituted Ion Channels
por: Efimova, Svetlana S., et al.
Publicado: (2023)

Aβ-Targeting Bifunctional Chelators (BFCs) for Potential Therapeutic and PET Imaging Applications
por: Krasnovskaya, Olga, et al.
Publicado: (2022)

Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion Peptides
por: Shekunov, Egor V., et al.
Publicado: (2021)

Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs
por: Shekunov, Egor V., et al.
Publicado: (2023)

The Interaction of Dipole Modifiers with Polyene-Sterol Complexes
por: Ostroumova, Olga S., et al.
Publicado: (2012)

The Degree of Hydroxylation of Phenolic Rings Determines the Ability of Flavonoids and Stilbenes to Inhibit Calcium-Mediated Membrane Fusion
por: Zlodeeva, Polina D., et al.
Publicado: (2023)

Carboranyl-Chlorin e(6) as a Potent Antimicrobial Photosensitizer
por: Omarova, Elena O., et al.
Publicado: (2015)

Discovery of the Potentiator of the Pore-Forming Ability of Lantibiotic Nisin: Perspectives for Anticancer Therapy
por: Chernyshova, Dayana N., et al.
Publicado: (2022)

3-Amino-Substituted Analogues of Fusidic Acid as Membrane-Active Antibacterial Compounds
por: Salimova, Elena V., et al.
Publicado: (2023)

The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development
por: Kuchur, O. A., et al.
Publicado: (2021)

Pt(IV) Prodrugs with NSAIDs as Axial Ligands
por: Spector, Daniil, et al.
Publicado: (2021)

Metals in Imaging of Alzheimer’s Disease
por: Krasnovskaya, Olga, et al.
Publicado: (2020)

Recent Advances in (64)Cu/(67)Cu-Based Radiopharmaceuticals
por: Krasnovskaya, Olga O., et al.
Publicado: (2023)

Investigation of Channel-Forming Activity of Polyene Macrolide Antibiotics in Planar Lipid Bilayers in the Presence of Dipole Modifiers
por: Efimova, S. S., et al.
Publicado: (2014)

Pore-forming activity of new conjugate antibiotics based on amphotericin B
por: Efimova, Svetlana S., et al.
Publicado: (2017)

How Macrophages Become Transcriptionally Dysregulated: A Hidden Impact of Antitumor Therapy
por: Medvedeva, Galina F., et al.
Publicado: (2021)

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes
por: Vasilichin, Vladislav A., et al.
Publicado: (2020)

Perfluorocarbon Nanoemulsions with Fluorous Chlorin-Type Photosensitizers for Antitumor Photodynamic Therapy in Hypoxia
por: Nguyen, Minh Tuan, et al.
Publicado: (2023)

Clinical Correlations of Polycomb Repressive Complex 2 in Different Tumor Types
por: Erokhin, Maksim, et al.
Publicado: (2021)

Modifiers of the Dipole Potential of Lipid Bilayers
por: Efimova, S. S., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lo4icaa91s278n0cu6vqmk6f9k