T3P-Promoted Synthesis of a Series of 2-Aryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones and Their Activity against the Kinetoplastid Parasite Trypanosoma brucei

A series of fourteen 2-aryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones was prepared at room temperature by T3P-mediated cyclization of N-phenyl-C-aryl imines with thionicotinic acid, two difficult substrates. The reactions were operationally simple, did not require specialized equipmen...

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Detalles Bibliográficos
Autores principales: Silverberg, Lee J., Mal, Tapas K., Pacheco, Carlos N., Povelones, Megan L., Malfara, Madeline F., Lagalante, Anthony F., Olsen, Mark A., Yennawar, Hemant P., Sobhi, Hany F., Baney, Kayla R., Bozeman, Robin L., Eroh, Craig S., Fleming, Michael J., Garcia, Tracy L., Gregory, Casey L., Hahn, Julia E., Hatter, Alyssa M., Johns, Lexi L., Klinger, Tianna L., Li, Jennie J., Menig, Andrew J., Muench, Grace C., Ramirez, Melissa E., Reilly, Jordyn, Sacco, Nicole, Sheidy, Alexandra M., Stoner, Marla M., Thompson, Eric N., Yazdani, Soroush F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540051/
https://www.ncbi.nlm.nih.gov/pubmed/34684680
http://dx.doi.org/10.3390/molecules26206099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540051/
https://www.ncbi.nlm.nih.gov/pubmed/34684680
http://dx.doi.org/10.3390/molecules26206099

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