Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers

The SF3B1 protein, part of the SF3b complex, recognizes the intron branch point sequence of precursor messenger RNA (pre-mRNA), thus contributing to splicing fidelity. SF3B1 is frequently mutated in cancer and is the target of distinct families of splicing modulators (SMs). Among these, H3B-8800 is...

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Detalles Bibliográficos
Autores principales: Spinello, Angelo, Borišek, Jure, Malcovati, Luca, Magistrato, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540225/
https://www.ncbi.nlm.nih.gov/pubmed/34681880
http://dx.doi.org/10.3390/ijms222011222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540225/
https://www.ncbi.nlm.nih.gov/pubmed/34681880
http://dx.doi.org/10.3390/ijms222011222

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