Cargando…

Synthesis, Computational Analysis, and Antiproliferative Activity of Novel Benzimidazole Acrylonitriles as Tubulin Polymerization Inhibitors: Part 2

We used classical linear and microwave-assisted synthesis methods to prepare novel N-substituted, benzimidazole-derived acrylonitriles with antiproliferative activity against several cancer cells in vitro. The most potent systems showed pronounced activity against all tested hematological cancer cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beč, Anja, Hok, Lucija, Persoons, Leentje, Vanstreels, Els, Daelemans, Dirk, Vianello, Robert, Hranjec, Marijana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540608/ https://www.ncbi.nlm.nih.gov/pubmed/34681276 http://dx.doi.org/10.3390/ph14101052

Ejemplares similares

Novel Biologically Active N-Substituted Benzimidazole Derived Schiff Bases: Design, Synthesis, and Biological Evaluation
por: Beč, Anja, et al.
Publicado: (2023)

Synthesis and Antiproliferative Activity of 2,6-Disubstituted Imidazo[4,5-b]pyridines Prepared by Suzuki Cross Coupling
por: Boček Pavlinac, Ida, et al.
Publicado: (2023)

Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity
por: Cindrić, Maja, et al.
Publicado: (2019)

Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)
por: Gargantilla, Marta, et al.
Publicado: (2022)

Biological Activity of Amidino-Substituted Imidazo [4,5-b]pyridines
por: Pavlinac, Ida Boček, et al.
Publicado: (2022)

Preparation of Antiproliferative Terpene-Alkaloid Hybrids by Free Radical-Mediated Modification of ent-Kauranic Derivatives
por: Pruteanu, Elena, et al.
Publicado: (2021)

Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides
por: Beč, Anja, et al.
Publicado: (2022)

Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity
por: Cuartas, Viviana, et al.
Publicado: (2019)

Design and Antiproliferative Evaluation of Novel Sulfanilamide Derivatives as Potential Tubulin Polymerization Inhibitors
por: Fu, Dong-Jun, et al.
Publicado: (2017)

Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles
por: Racané, Livio, et al.
Publicado: (2021)

Biological Activity of Newly Synthesized Benzimidazole and Benzothizole 2,5-Disubstituted Furane Derivatives
por: Racané, Livio, et al.
Publicado: (2021)

Synthesis and biological evaluation of 2-aryl-benzimidazole derivatives of dehydroabietic acid as novel tubulin polymerization inhibitors
por: Miao, Ting-Ting, et al.
Publicado: (2018)

Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones
por: Argirova, Maria, et al.
Publicado: (2022)

Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles
por: Das, Arnika, et al.
Publicado: (2021)

Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
por: Zhang, Yu, et al.
Publicado: (2019)

Synthesis, Antiproliferative Evaluation and QSAR Analysis of Novel Halogen- and Amidino-Substituted Benzothiazoles and Benzimidazoles
por: Rep Kaulić, Valentina, et al.
Publicado: (2022)

Discovery of ( ±)-3-(1 H -pyrazol-1-yl)-6,7-dihydro-5 H -[1,2,4]triazolo[3,4- b ][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity
por: Jilloju, Parameshwara Chary, et al.
Publicado: (2021)

Molecular docking and dynamic simulations of benzimidazoles with beta-tubulins
por: Rao, Chennu Maruthi Malya Prasada, et al.
Publicado: (2021)

Heterozygous mutation of cysteine(528) in XPO1 is sufficient for resistance to selective inhibitors of nuclear export
por: Neggers, Jasper Edgar, et al.
Publicado: (2016)

Synthesis and biological evaluation of novel quinolone derivatives dual targeting histone deacetylase and tubulin polymerization as antiproliferative agents
por: Wang, Xuan, et al.
Publicado: (2018)

Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
por: Gargantilla, Marta, et al.
Publicado: (2021)

Anthranilamides with quinoline and β-carboline scaffolds: design, synthesis, and biological activity
por: Beus, Maja, et al.
Publicado: (2022)

Benzimidazole scaffolds as promising antiproliferative agents: a review
por: Tahlan, Sumit, et al.
Publicado: (2019)

Physiological regulation of total tubulin and polymerized tubulin in tissues
Publicado: (1977)

Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones
por: Leese, Mathew P, et al.
Publicado: (2014)

Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity
por: Fu, Dong-Jun, et al.
Publicado: (2022)

Acrylonitrile
Publicado: (2002)

Sulfhydryls and the in vitro polymerization of tubulin
Publicado: (1976)

Synthesis and Antiproliferative Activities of Benzimidazole-Based Sulfide and Sulfoxide Derivatives
por: Gaballah, Samir T., et al.
Publicado: (2016)

Poly(acrylonitrile-co-butadiene) as polymeric crosslinking accelerator for sulphur network formation
por: Hait, Sakrit, et al.
Publicado: (2020)

Taxol binds to polymerized tubulin in vitro
por: Parness, J, et al.
Publicado: (1981)

Mapping the Binding Interface between an HIV-1 Inhibiting Intrabody and the Viral Protein Rev
por: Vercruysse, Thomas, et al.
Publicado: (2013)

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles
por: Dilks, Clayton M., et al.
Publicado: (2020)

Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
por: Palma, Adalid, et al.
Publicado: (2020)

Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles
por: Dilks, Clayton M., et al.
Publicado: (2021)

Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin
por: Gibson, Sophia B., et al.
Publicado: (2022)

Direct Metal-Free Transformation of Alkynes to Nitriles: Computational Evidence for the Precise Reaction Mechanism
por: Hok, Lucija, et al.
Publicado: (2021)

Study on initiating approach of (3-(tert-butylperoxy)propyl) trimethoxysilane on the polymerization of acrylonitrile as an initiator
por: Wang, Yazhen, et al.
Publicado: (2017)

Synthesis and in Vitro Antiproliferative Evaluation of Some B-norcholesteryl Benzimidazole and Benzothiazole Derivatives
por: Cui, Jianguo, et al.
Publicado: (2015)

Antiproliferative Aspect of Benzimidazole Derivatives’ Activity and Their Impact on NF-κB Expression
por: Błaszczak-Świątkiewicz, Katarzyna
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_46si4t0podrpmuqeq7j5n694c7