Dual Targeting of PTP1B and Aldose Reductase with Marine Drug Phosphoeleganin: A Promising Strategy for Treatment of Type 2 Diabetes

An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes, including analysis of the insulin signalling pathway, of phosphoeleganin, a marine-derived phosphorylated polyketide, was achieved. Phosphoeleganin was demonstrated to inhibit...

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Detalles Bibliográficos
Autores principales: Genovese, Massimo, Imperatore, Concetta, Casertano, Marcello, Aiello, Anna, Balestri, Francesco, Piazza, Lucia, Menna, Marialuisa, Del Corso, Antonella, Paoli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540617/
https://www.ncbi.nlm.nih.gov/pubmed/34677434
http://dx.doi.org/10.3390/md19100535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540617/
https://www.ncbi.nlm.nih.gov/pubmed/34677434
http://dx.doi.org/10.3390/md19100535

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