Cargando…

Dual Targeting of PTP1B and Aldose Reductase with Marine Drug Phosphoeleganin: A Promising Strategy for Treatment of Type 2 Diabetes

An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes, including analysis of the insulin signalling pathway, of phosphoeleganin, a marine-derived phosphorylated polyketide, was achieved. Phosphoeleganin was demonstrated to inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Genovese, Massimo, Imperatore, Concetta, Casertano, Marcello, Aiello, Anna, Balestri, Francesco, Piazza, Lucia, Menna, Marialuisa, Del Corso, Antonella, Paoli, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540617/ https://www.ncbi.nlm.nih.gov/pubmed/34677434 http://dx.doi.org/10.3390/md19100535

Ejemplares similares

Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara
por: Casertano, Marcello, et al.
Publicado: (2023)

Identifying Human PTP1B Enzyme Inhibitors from Marine Natural Products: Perspectives for Developing of Novel Insulin-Mimetic Drugs
por: Casertano, Marcello, et al.
Publicado: (2022)

Insights into Cytotoxic Behavior of Lepadins and Structure Elucidation of the New Alkaloid Lepadin L from the Mediterranean Ascidian Clavelina lepadiformis
por: Casertano, Marcello, et al.
Publicado: (2022)

Natural Bioactive Compounds from Marine Invertebrates That Modulate Key Targets Implicated in the Onset of Type 2 Diabetes Mellitus (T2DM) and Its Complications
por: Casertano, Marcello, et al.
Publicado: (2023)

In Search of Differential Inhibitors of Aldose Reductase
por: Balestri, Francesco, et al.
Publicado: (2022)

The Ascidian-Derived Metabolites with Antimicrobial Properties
por: Casertano, Marcello, et al.
Publicado: (2020)

In Vitro Antiproliferative Evaluation of Synthetic Meroterpenes Inspired by Marine Natural Products
por: Imperatore, Concetta, et al.
Publicado: (2019)

Aldose Reductase Differential Inhibitors in Green Tea
por: Balestri, Francesco, et al.
Publicado: (2020)

Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches
por: Balestri, Francesco, et al.
Publicado: (2022)

Meroterpenes from Marine Invertebrates: Structures, Occurrence, and Ecological Implications
por: Menna, Marialuisa, et al.
Publicado: (2013)

A New Approach to Control the Enigmatic Activity of Aldose Reductase
por: Del-Corso, Antonella, et al.
Publicado: (2013)

The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase
por: Misuri, Livia, et al.
Publicado: (2017)

Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct
por: Balestri, Francesco, et al.
Publicado: (2019)

Chemical Investigation of the Indonesian Tunicate Polycarpa aurata and Evaluation of the Effects Against Schistosoma mansoni of the Novel Alkaloids Polyaurines A and B
por: Casertano, Marcello, et al.
Publicado: (2019)

Alkaloids from Marine Ascidians
por: Menna, Marialuisa, et al.
Publicado: (2011)

Soyasaponins from Zolfino bean as aldose reductase differential inhibitors
por: Balestri, Francesco, et al.
Publicado: (2018)

Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
por: Imperatore, Concetta, et al.
Publicado: (2014)

Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase
por: Balestri, Francesco, et al.
Publicado: (2022)

Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections
por: Casertano, Marcello, et al.
Publicado: (2020)

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone
por: Imperatore, Concetta, et al.
Publicado: (2020)

Response of a Human Lens Epithelial Cell Line to Hyperglycemic and Oxidative Stress: The Role of Aldose Reductase
por: Sardelli, Gemma, et al.
Publicado: (2023)

Insight into the Mechanism of Action of Marine Cytotoxic Thiazinoquinones
por: Imperatore, Concetta, et al.
Publicado: (2017)

Physiological and Pathological Roles of Aldose Reductase
por: Singh, Mahavir, et al.
Publicado: (2021)

In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B
por: Ottanà, Rosaria, et al.
Publicado: (2021)

Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
por: Aiello, Anna, et al.
Publicado: (2010)

Aplisulfamines, New Sulfoxide-Containing Metabolites from an Aplidium Tunicate: Absolute Stereochemistry at Chiral Sulfur and Carbon Atoms Assigned Through an Original Combination of Spectroscopic and Computational Methods
por: Aiello, Anna, et al.
Publicado: (2012)

Structure of aldose reductase from Giardia lamblia
por: Ferrell, M., et al.
Publicado: (2011)

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus
por: Tang, Wai Ho, et al.
Publicado: (2012)

Inhibition of Aldose Reductase by Gentiana lutea Extracts
por: Akileshwari, Chandrasekhar, et al.
Publicado: (2012)

Human aldose reductase unfolds through an intermediate
por: Sekhon, Gurprit, et al.
Publicado: (2019)

Molecular docking analysis of flavonoids with aldose reductase
por: Kannayiram, Kasthuri, et al.
Publicado: (2022)

Aldose Reductase Gene Polymorphisms and Diabetic Retinopathy Susceptibility
por: Abhary, Sotoodeh, et al.
Publicado: (2010)

Tracer metabolomics reveals the role of aldose reductase in glycosylation
por: Radenkovic, Silvia, et al.
Publicado: (2023)

Spectroscopic Properties of Two 5′-(4-Dimethylamino)Azobenzene Conjugated G-Quadruplex Forming Oligonucleotides
por: Imperatore, Concetta, et al.
Publicado: (2020)

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications
por: Kovacikova, Lucia, et al.
Publicado: (2021)

Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
por: Menna, Marialuisa, et al.
Publicado: (2012)

Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
por: Reddy, G. Bhanuprakash, et al.
Publicado: (2008)

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells
por: Yadav, Umesh C. S., et al.
Publicado: (2010)

Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts
por: Karasu, Çimen, et al.
Publicado: (2012)

Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective
por: Sharma, S. R., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_p0vcurhb70dnb3klrfe65buil7