Evaluation of Aminopolycarboxylate Chelators for Whole-Body Clearance of Free (225)Ac: A Feasibility Study to Reduce Unexpected Radiation Exposure during Targeted Alpha Therapy

Actinium-225 ((225)Ac) is a promising radionuclide used in targeted alpha therapy (TAT). Although (225)Ac labeling of bifunctional chelating ligands is effective, previous in vivo studies reported that free (225)Ac can be released from the drugs and that such free (225)Ac is predominantly accumulate...

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Detalles Bibliográficos
Autores principales: Yoshimoto, Mitsuyoshi, Yoshii, Yukie, Matsumoto, Hiroki, Shinada, Mitsuhiro, Takahashi, Masashi, Igarashi, Chika, Hihara, Fukiko, Tachibana, Tomoko, Doi, Ayano, Higashi, Tatsuya, Fujii, Hirofumi, Washiyama, Kohshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540721/
https://www.ncbi.nlm.nih.gov/pubmed/34683999
http://dx.doi.org/10.3390/pharmaceutics13101706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540721/
https://www.ncbi.nlm.nih.gov/pubmed/34683999
http://dx.doi.org/10.3390/pharmaceutics13101706

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