Pyrrolizidine Alkaloid-Induced Hepatotoxicity Associated with the Formation of Reactive Metabolite-Derived Pyrrole–Protein Adducts

Pyrrolizidine alkaloids (PAs) with 1,2-unsaturated necine base are hepatotoxic phytotoxins. Acute PA intoxication is initiated by the formation of adducts between PA-derived reactive pyrrolic metabolites with cellular proteins. The present study aimed to investigate the correlation between the forma...

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Detalles Bibliográficos
Autores principales: Ma, Jiang, Li, Mi, Li, Na, Chan, Wood Yee, Lin, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540779/
https://www.ncbi.nlm.nih.gov/pubmed/34679016
http://dx.doi.org/10.3390/toxins13100723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540779/
https://www.ncbi.nlm.nih.gov/pubmed/34679016
http://dx.doi.org/10.3390/toxins13100723

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