Pleiotropic Effects of Atorvastatin Result in a Downregulation of the Carboxypeptidase U System (CPU, TAFIa, CPB2) in a Mouse Model of Advanced Atherosclerosis

Statins (hydroxymethyl-glutaryl-CoA-reductase inhibitors) lower procarboxypeptidase U (proCPU, TAFI, proCPB2). However, it is challenging to prove whether this is a lipid or non-lipid-related pleiotropic effect, since statin treatment decreases cholesterol levels in humans. In apolipoprotein E-defic...

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Detalles Bibliográficos
Autores principales: Claesen, Karen, Roth, Lynn, Mertens, Joachim C., Hermans, Karlijn, Sim, Yani, Hendriks, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540817/
https://www.ncbi.nlm.nih.gov/pubmed/34684024
http://dx.doi.org/10.3390/pharmaceutics13101731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540817/
https://www.ncbi.nlm.nih.gov/pubmed/34684024
http://dx.doi.org/10.3390/pharmaceutics13101731

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