Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene. This mutation leads to the production of mutant HTT (mHTT) protein which triggers neuronal death through several mechanisms. Here, we investi...

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Detalles Bibliográficos
Autores principales: Pruccoli, Letizia, Breda, Carlo, Teti, Gabriella, Falconi, Mirella, Giorgini, Flaviano, Tarozzi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541026/
https://www.ncbi.nlm.nih.gov/pubmed/34681268
http://dx.doi.org/10.3390/ph14101044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541026/
https://www.ncbi.nlm.nih.gov/pubmed/34681268
http://dx.doi.org/10.3390/ph14101044

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