Cargando…

Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene. This mutation leads to the production of mutant HTT (mHTT) protein which triggers neuronal death through several mechanisms. Here, we investi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pruccoli, Letizia, Breda, Carlo, Teti, Gabriella, Falconi, Mirella, Giorgini, Flaviano, Tarozzi, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541026/ https://www.ncbi.nlm.nih.gov/pubmed/34681268 http://dx.doi.org/10.3390/ph14101044

Ejemplares similares

Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells
por: Pruccoli, Letizia, et al.
Publicado: (2020)

Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity
por: Tauber, Eran, et al.
Publicado: (2011)

Curcumin and Heme Oxygenase: Neuroprotection and Beyond
por: Mhillaj, Emanuela, et al.
Publicado: (2019)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
por: Cariulo, Cristina, et al.
Publicado: (2017)

Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin
por: Tan, Z, et al.
Publicado: (2015)

Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast
por: Kantcheva, Ralitsa B., et al.
Publicado: (2014)

Huntington’s Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy
por: Sari, Youssef
Publicado: (2011)

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington’s Disease
por: Osmand, Alexander P., et al.
Publicado: (2016)

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
por: Fodale, Valentina, et al.
Publicado: (2020)

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
por: Miguez, Andrés, et al.
Publicado: (2023)

Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane
por: Swaih, Aisha M., et al.
Publicado: (2022)

Connectivity mapping uncovers small molecules that modulate neurodegeneration in Huntington’s disease models
por: Smalley, Joshua L., et al.
Publicado: (2015)

Connecting the dots in Huntington's disease with protein interaction networks
por: Giorgini, Flaviano, et al.
Publicado: (2005)

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington’s Disease T Lymphocytes
por: Miller, James R. C., et al.
Publicado: (2015)

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients
por: Pierzynowska, Karolina, et al.
Publicado: (2019)

Glycation potentiates neurodegeneration in models of Huntington’s disease
por: Vicente Miranda, Hugo, et al.
Publicado: (2016)

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin
por: Galvan, Laurie, et al.
Publicado: (2018)

Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice
por: Wang, Nan, et al.
Publicado: (2014)

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
por: Ehrnhoefer, Dagmar E., et al.
Publicado: (2018)

Mutant Huntingtin Affects Diabetes and Alzheimer’s Markers in Human and Cell Models of Huntington’s Disease
por: Chaves, Gepoliano, et al.
Publicado: (2019)

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models
por: Schulze-Krebs, Anja, et al.
Publicado: (2021)

Effects of mutant huntingtin inactivation on Huntington disease‐related behaviours in the BACHD mouse model
por: Cheong, Rachel Y., et al.
Publicado: (2021)

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients
por: Skotte, Niels H., et al.
Publicado: (2014)

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
por: Luo, Shouqing, et al.
Publicado: (2005)

Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease
por: Vittori, Angelica, et al.
Publicado: (2014)

Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
por: Aron, Rebecca, et al.
Publicado: (2018)

Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models
por: Yu, Meng, et al.
Publicado: (2017)

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
por: Niu, Li, et al.
Publicado: (2018)

Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington’s disease cell models
por: Aravindan, Shreyaas, et al.
Publicado: (2020)

Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene
por: Franich, Nicholas R., et al.
Publicado: (2019)

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
por: Eshraghi, Mehdi, et al.
Publicado: (2021)

Mutant Huntingtin Derails Cysteine Metabolism in Huntington’s Disease at Both Transcriptional and Post-Translational Levels
por: Paul, Bindu D., et al.
Publicado: (2022)

Integrative determination of the atomic structure of mutant huntingtin exon 1 fibrils from Huntington’s disease
por: Helabad, Mahdi Bagherpoor, et al.
Publicado: (2023)

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia
por: Stöberl, Nina, et al.
Publicado: (2023)

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
por: Aron, Rebecca, et al.
Publicado: (2018)

Huntingtin Aggregates in the Olfactory Bulb in Huntington’s Disease
por: Highet, Blake, et al.
Publicado: (2020)

Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
por: van der Bent, M Leontien, et al.
Publicado: (2022)

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity
por: Watkin, Erin E., et al.
Publicado: (2014)

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction
por: Weiss, Andreas, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_kqggh2r9dnun7m9lv9itd18p21