Reversal Activity and Toxicity of Heparin-Binding Copolymer after Subcutaneous Administration of Enoxaparin in Mice

Uncontrolled bleeding after enoxaparin (ENX) is rare but may be life-threatening. The only registered antidote for ENX, protamine sulfate (PS), has 60% efficacy and can cause severe adverse side effects. We developed a diblock copolymer, heparin-binding copolymer (HBC), that reverses intravenously a...

Descripción completa

Detalles Bibliográficos
Autores principales: Swieton, Justyna, Miklosz, Joanna, Yusa, Shin-Ichi, Szczubialka, Krzysztof, Pawlak, Dariusz, Mogielnicki, Andrzej, Kalaska, Bartlomiej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541278/
https://www.ncbi.nlm.nih.gov/pubmed/34681808
http://dx.doi.org/10.3390/ijms222011149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541278/
https://www.ncbi.nlm.nih.gov/pubmed/34681808
http://dx.doi.org/10.3390/ijms222011149

Ejemplares similares