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Effects of Impurities from Sugar Excipient on Filtrate Flux during Ultrafiltration and Diafiltration Process
Sugar excipients such as sucrose and maltose are widely used for biopharmaceutical formulation to improve protein stability and to ensure isotonicity for administration. However, according to recent literature, pharmaceutical-grade sucrose contained nanoparticulate impurities (NPIs) that result in p...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541299/ https://www.ncbi.nlm.nih.gov/pubmed/34677543 http://dx.doi.org/10.3390/membranes11100775 |