Expression, Purification and Refolding of a Human Na(V)1.7 Voltage Sensing Domain with Native-like Toxin Binding Properties

The voltage-gated sodium channel Na(V)1.7 is an important target for drug development due to its role in pain perception. Recombinant expression of full-length channels and their use for biophysical characterization of interactions with potential drug candidates is challenging due to the protein siz...

Descripción completa

Detalles Bibliográficos
Autores principales: Schroder, Ryan V., Cohen, Leah S., Wang, Ping, Arizala, Joekeem D., Poget, Sébastien F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541342/
https://www.ncbi.nlm.nih.gov/pubmed/34679015
http://dx.doi.org/10.3390/toxins13100722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541342/
https://www.ncbi.nlm.nih.gov/pubmed/34679015
http://dx.doi.org/10.3390/toxins13100722

Ejemplares similares