Cargando…

Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R

The aminoglycoside gentamicin is used for the empirical treatment of pediatric infections. It has a narrow therapeutic window. In this prospective study at University Children’s Hospital Zurich, Switzerland, we aimed to characterize the pharmacokinetics of gentamicin in pediatric patients and predic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paioni, Paolo, Jäggi, Vera F., Tilen, Romy, Seiler, Michelle, Baumann, Philipp, Bräm, Dominic S., Jetzer, Carole, Haid, Robin T. U., Goetschi, Aljoscha N., Goers, Roland, Müller, Daniel, Coman Schmid, Diana, Meyer zu Schwabedissen, Henriette E., Rinn, Bernd, Berger, Christoph, Krämer, Stefanie D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541459/ https://www.ncbi.nlm.nih.gov/pubmed/34683889 http://dx.doi.org/10.3390/pharmaceutics13101596

Ejemplares similares

Pharmacogenetic Analysis of Voriconazole Treatment in Children
por: Tilen, Romy, et al.
Publicado: (2022)

SwissPK(cdw) – A clinical data warehouse for the optimization of pediatric dosing regimens
por: Goers, Roland, et al.
Publicado: (2021)

Development of the Swiss Database for dosing medicinal products in pediatrics
por: Tilen, Romy, et al.
Publicado: (2021)

CYP2D6 function moderates the pharmacokinetics and pharmacodynamics of 3,4-methylene-dioxymethamphetamine in a controlled study in healthy individuals
por: Schmid, Yasmin, et al.
Publicado: (2016)

No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA
por: Vizeli, Patrick, et al.
Publicado: (2017)

Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy—Modulators of Cellular Entry or Pharmacokinetics?
por: Brecht, Karin, et al.
Publicado: (2020)

Expression and Function of Organic Anion Transporting Polypeptides in the Human Brain: Physiological and Pharmacological Implications
por: Schäfer, Anima M., et al.
Publicado: (2021)

Clinical relevance of St. John's wort drug interactions revisited
por: Nicolussi, Simon, et al.
Publicado: (2020)

Cytochrome P450 1A2 is the most important enzyme for hepatic metabolism of the metamizole metabolite 4‐methylaminoantipyrine
por: Bachmann, Fabio, et al.
Publicado: (2021)

Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? – A Case Report
por: Jeiziner, Chiara, et al.
Publicado: (2022)

Pharmacogenetic testing and counselling in the community pharmacy: mixed-methods study of a new pharmacist-led service
por: Jeiziner, Chiara, et al.
Publicado: (2023)

Comment on Shaniv et al. Neonatal Drug Formularies—A Global Scope. Children 2023, 10, 848
por: Giger, Elisabeth V., et al.
Publicado: (2023)

An evaluation of serum gentamicin concentrations and bacterial susceptibility to gentamicin in equine practice
por: Durham, Andy E.
Publicado: (2018)

Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report
por: Meyer zu Schwabedissen, Henriette E, et al.
Publicado: (2014)

PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism
por: Ehrsam, Daniel, et al.
Publicado: (2019)

Methyltransferases of gentamicin biosynthesis
por: Li, Sicong, et al.
Publicado: (2018)

Oxiconazole Potentiates Gentamicin against Gentamicin-Resistant Staphylococcus aureus In Vitro and In Vivo
por: Kaul, Grace, et al.
Publicado: (2023)

HLA‐associated adverse drug reactions ‐ scoping review
por: Jeiziner, Chiara, et al.
Publicado: (2021)

Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex
por: Huang, Chuan, et al.
Publicado: (2015)

Plasma Peak and Trough Gentamicin Concentrations in Hospitalized Horses Receiving Intravenously Administered Gentamicin
por: Bauquier, J.R., et al.
Publicado: (2015)

Biodegradation of gentamicin by bacterial consortia AMQD4 in synthetic medium and raw gentamicin sewage
por: Liu, Yuanwang, et al.
Publicado: (2017)

Intratympanic Gentamicin Versus Labyrinthectomy: Inner Ear Sensitivity to Gentamicin and Impact on the Contralateral Labyrinth
por: Kontorinis, Georgios, et al.
Publicado: (2019)

1314. Neonatal Serum Gentamicin Concentrations following Maternal Once-daily Gentamicin Dosing
por: Wilson, Genene A, et al.
Publicado: (2020)

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta
por: Taggi, Valerio, et al.
Publicado: (2022)

Various effects of repeated rifampin dosing on coproporphyrin levels in humans
por: Kinzi, Jonny, et al.
Publicado: (2023)

Tetany in association with gentamicin therapy.
por: Beatty, O. L., et al.
Publicado: (1989)

Once-daily dosing of gentamicin.
por: Soper, D E
Publicado: (1998)

Intratympanic gentamicin for Ménière’s disease
por: Webster, Katie E, et al.
Publicado: (2023)

Patients’ safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?
por: Moghaddam, Arash, et al.
Publicado: (2016)

P34 Gentamicin labels: improving the timing of gentamicin levels and reducing delay in dose administrations
por: Zakariya, Muhammad Zakwan, et al.
Publicado: (2023)

Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions
por: Jeiziner, Chiara, et al.
Publicado: (2021)

Pharmacogenetics in Pharmaceutical Care—Piloting an Application-Oriented Blended Learning Concept
por: Stäuble, Céline K., et al.
Publicado: (2021)

Pharmacogenetic Analysis Enables Optimization of Pain Therapy: A Case Report of Ineffective Oxycodone Therapy
por: Wiss, Florine M., et al.
Publicado: (2023)

Sub-inhibitory gentamicin pollution induces gentamicin resistance gene integration in class 1 integrons in the environment
por: Sanchez-Cid, Concepcion, et al.
Publicado: (2023)

Gentamicin Release Study in Uniaxial and Coaxial Polyhydroxybutyrate–Polyethylene Glycol–Gentamicin Microfibers Treated with Atmospheric Plasma
por: Transito-Medina, Josselyne, et al.
Publicado: (2023)

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2
por: Bachmann, Fabio, et al.
Publicado: (2021)

Predictive performance of gentamicin dosing nomograms
por: Lee, Jieon, et al.
Publicado: (2014)

Paraprotein interference with turbidimetric gentamicin assay
por: Dimeski, Goce, et al.
Publicado: (2015)

Improving the correct prescription and dosage of gentamicin
por: Qureshi, Dr. Imran, et al.
Publicado: (2012)

Arbutin attenuates nephrotoxicity induced by gentamicin
por: Emadi, Elnaz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a9fn1988l8nq32pfr3rn097lre