Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541537/ https://www.ncbi.nlm.nih.gov/pubmed/34685388 http://dx.doi.org/10.3390/life11101017 |
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author | Detsika, Maria. G. Giatra, Chara Kitsiou, Vasiliki Jahaj, Edison Athanassiades, Theofilos Kouniaki, Diamanto Orfanos, Stylianos E. Dimopoulou, Ioanna Pagoni, Maria Tarassi, Katerina Tsirogianni, Alexandra Kotanidou, Anastasia |
author_facet | Detsika, Maria. G. Giatra, Chara Kitsiou, Vasiliki Jahaj, Edison Athanassiades, Theofilos Kouniaki, Diamanto Orfanos, Stylianos E. Dimopoulou, Ioanna Pagoni, Maria Tarassi, Katerina Tsirogianni, Alexandra Kotanidou, Anastasia |
author_sort | Detsika, Maria. G. |
collection | PubMed |
description | The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mild n = 69) and hospitalized (n = 56). Analysis of disease characteristics revealed no major differences between males and females of each group of patients while hospitalized patients were older and presented with comorbidities. A positive allele association was observed for HLA-DRB1*01 in total COVID-19 patients versus healthy controls. Subgrouping of COVID-19 patients in mild and hospitalized further identified a statistically significant increase in HLA-DRB1*01 in mild COVID-19 patients versus controls. The frequency of A*11, A*23, and DRB1*09 alleles was higher, while the frequency of C*12 was lower, in hospitalized patients versus healthy controls albeit with uncorrected statistical significance. The identification of specific allele associations may provide useful future markers for disease susceptibility in order to allow successful clinical management of COVID-19 patients. |
format | Online Article Text |
id | pubmed-8541537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85415372021-10-24 Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients Detsika, Maria. G. Giatra, Chara Kitsiou, Vasiliki Jahaj, Edison Athanassiades, Theofilos Kouniaki, Diamanto Orfanos, Stylianos E. Dimopoulou, Ioanna Pagoni, Maria Tarassi, Katerina Tsirogianni, Alexandra Kotanidou, Anastasia Life (Basel) Article The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mild n = 69) and hospitalized (n = 56). Analysis of disease characteristics revealed no major differences between males and females of each group of patients while hospitalized patients were older and presented with comorbidities. A positive allele association was observed for HLA-DRB1*01 in total COVID-19 patients versus healthy controls. Subgrouping of COVID-19 patients in mild and hospitalized further identified a statistically significant increase in HLA-DRB1*01 in mild COVID-19 patients versus controls. The frequency of A*11, A*23, and DRB1*09 alleles was higher, while the frequency of C*12 was lower, in hospitalized patients versus healthy controls albeit with uncorrected statistical significance. The identification of specific allele associations may provide useful future markers for disease susceptibility in order to allow successful clinical management of COVID-19 patients. MDPI 2021-09-27 /pmc/articles/PMC8541537/ /pubmed/34685388 http://dx.doi.org/10.3390/life11101017 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Detsika, Maria. G. Giatra, Chara Kitsiou, Vasiliki Jahaj, Edison Athanassiades, Theofilos Kouniaki, Diamanto Orfanos, Stylianos E. Dimopoulou, Ioanna Pagoni, Maria Tarassi, Katerina Tsirogianni, Alexandra Kotanidou, Anastasia Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
title | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
title_full | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
title_fullStr | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
title_full_unstemmed | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
title_short | Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients |
title_sort | demographic, clinical and immunogenetic profiles of a greek cohort of covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541537/ https://www.ncbi.nlm.nih.gov/pubmed/34685388 http://dx.doi.org/10.3390/life11101017 |
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