Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients

The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mi...

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Autores principales: Detsika, Maria. G., Giatra, Chara, Kitsiou, Vasiliki, Jahaj, Edison, Athanassiades, Theofilos, Kouniaki, Diamanto, Orfanos, Stylianos E., Dimopoulou, Ioanna, Pagoni, Maria, Tarassi, Katerina, Tsirogianni, Alexandra, Kotanidou, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541537/
https://www.ncbi.nlm.nih.gov/pubmed/34685388
http://dx.doi.org/10.3390/life11101017
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author Detsika, Maria. G.
Giatra, Chara
Kitsiou, Vasiliki
Jahaj, Edison
Athanassiades, Theofilos
Kouniaki, Diamanto
Orfanos, Stylianos E.
Dimopoulou, Ioanna
Pagoni, Maria
Tarassi, Katerina
Tsirogianni, Alexandra
Kotanidou, Anastasia
author_facet Detsika, Maria. G.
Giatra, Chara
Kitsiou, Vasiliki
Jahaj, Edison
Athanassiades, Theofilos
Kouniaki, Diamanto
Orfanos, Stylianos E.
Dimopoulou, Ioanna
Pagoni, Maria
Tarassi, Katerina
Tsirogianni, Alexandra
Kotanidou, Anastasia
author_sort Detsika, Maria. G.
collection PubMed
description The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mild n = 69) and hospitalized (n = 56). Analysis of disease characteristics revealed no major differences between males and females of each group of patients while hospitalized patients were older and presented with comorbidities. A positive allele association was observed for HLA-DRB1*01 in total COVID-19 patients versus healthy controls. Subgrouping of COVID-19 patients in mild and hospitalized further identified a statistically significant increase in HLA-DRB1*01 in mild COVID-19 patients versus controls. The frequency of A*11, A*23, and DRB1*09 alleles was higher, while the frequency of C*12 was lower, in hospitalized patients versus healthy controls albeit with uncorrected statistical significance. The identification of specific allele associations may provide useful future markers for disease susceptibility in order to allow successful clinical management of COVID-19 patients.
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spelling pubmed-85415372021-10-24 Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients Detsika, Maria. G. Giatra, Chara Kitsiou, Vasiliki Jahaj, Edison Athanassiades, Theofilos Kouniaki, Diamanto Orfanos, Stylianos E. Dimopoulou, Ioanna Pagoni, Maria Tarassi, Katerina Tsirogianni, Alexandra Kotanidou, Anastasia Life (Basel) Article The present cross-sectional study consists of a comprehensive analysis of epidemiological, laboratory, and clinical characteristics of COVID-19 patients in relation to their immunogenetic profiles. We studied 125 COVID-19 patients comprising different stages of disease severity; non-hospitalized (mild n = 69) and hospitalized (n = 56). Analysis of disease characteristics revealed no major differences between males and females of each group of patients while hospitalized patients were older and presented with comorbidities. A positive allele association was observed for HLA-DRB1*01 in total COVID-19 patients versus healthy controls. Subgrouping of COVID-19 patients in mild and hospitalized further identified a statistically significant increase in HLA-DRB1*01 in mild COVID-19 patients versus controls. The frequency of A*11, A*23, and DRB1*09 alleles was higher, while the frequency of C*12 was lower, in hospitalized patients versus healthy controls albeit with uncorrected statistical significance. The identification of specific allele associations may provide useful future markers for disease susceptibility in order to allow successful clinical management of COVID-19 patients. MDPI 2021-09-27 /pmc/articles/PMC8541537/ /pubmed/34685388 http://dx.doi.org/10.3390/life11101017 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Detsika, Maria. G.
Giatra, Chara
Kitsiou, Vasiliki
Jahaj, Edison
Athanassiades, Theofilos
Kouniaki, Diamanto
Orfanos, Stylianos E.
Dimopoulou, Ioanna
Pagoni, Maria
Tarassi, Katerina
Tsirogianni, Alexandra
Kotanidou, Anastasia
Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
title Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
title_full Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
title_fullStr Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
title_full_unstemmed Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
title_short Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 Patients
title_sort demographic, clinical and immunogenetic profiles of a greek cohort of covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541537/
https://www.ncbi.nlm.nih.gov/pubmed/34685388
http://dx.doi.org/10.3390/life11101017
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