A Novel Statin Compound from Monacolin J Produced Using CYP102A1-Catalyzed Regioselective C-Hydroxylation

Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), which is the rate-limiting enzyme in cholesterol biosynthesis. Statin therapy reduces morbidity and mortality in those who are at high risk of cardiovascular disease. Monacolin J is a statin compound, which is...

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Detalles Bibliográficos
Autores principales: Cao, Ngoc Tan, Nguyen, Ngoc Anh, Park, Chan Mi, Cha, Gun Su, Park, Ki Deok, Yun, Chul-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541633/
https://www.ncbi.nlm.nih.gov/pubmed/34681205
http://dx.doi.org/10.3390/ph14100981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8541633/
https://www.ncbi.nlm.nih.gov/pubmed/34681205
http://dx.doi.org/10.3390/ph14100981

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