Cargando…

Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis

Both tumor cell-intrinsic signals and tumor cell-extrinsic signals from cells within the tumor microenvironment influence tumor cell dissemination and metastasis. The fibrillar collagen receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) is essential for breast cancer metastasis in mou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barcus, Craig E., Hwang, Priscilla Y., Morikis, Vasilios, Brenot, Audrey, Pence, Patrick, Clarke, Maria, Longmore, Gregory D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542384/ https://www.ncbi.nlm.nih.gov/pubmed/34477203 http://dx.doi.org/10.1242/jcs.258431

Ejemplares similares

DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs
por: Bayer, Samantha VH, et al.
Publicado: (2019)

A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration
por: Hwang, Priscilla Y., et al.
Publicado: (2023)

SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion
por: Brenot, Audrey, et al.
Publicado: (2018)

Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain
por: Grither, Whitney R., et al.
Publicado: (2018)

DDR2 Expression in Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion and Metastasis through Periostin-ITGB1
por: Akinjiyan, Favour A., et al.
Publicado: (2022)

New functions of DDR1 collagen receptor in tumor dormancy, immune exclusion and therapeutic resistance
por: Sirvent, Audrey, et al.
Publicado: (2022)

Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors
por: Singh, Vibha, et al.
Publicado: (2019)

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
por: Kim, Hyung-Gu, et al.
Publicado: (2013)

Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
por: Kim, Hyung-Gu, et al.
Publicado: (2014)

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2
por: Slocum, Elizabeth, et al.
Publicado: (2019)

Targeting DDR2 enhances tumor response to anti–PD-1 immunotherapy
por: Tu, Megan M., et al.
Publicado: (2019)

Barring the gates to the battleground: DDR1 promotes immune exclusion in solid tumors
por: Wagner, Dimitrios L., et al.
Publicado: (2022)

Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma
por: Berestjuk, Ilona, et al.
Publicado: (2021)

Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration
por: Fowler, Alan J., et al.
Publicado: (2019)

DDR-mediated crosstalk between DNA-damaged cells and their microenvironment
por: Malaquin, Nicolas, et al.
Publicado: (2015)

A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance
por: Yang, Longfei, et al.
Publicado: (2023)

Overexpression of DDR1 Promotes Migration, Invasion, Though EMT-Related Molecule Expression and COL4A1/DDR1/MMP-2 Signaling Axis
por: Xie, Xin, et al.
Publicado: (2020)

BMI1, ATM and DDR
por: Lin, Xiaozeng, et al.
Publicado: (2015)

The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis
por: Carracedo, Miguel, et al.
Publicado: (2022)

DDR1 inhibition as a new therapeutic strategy for colorectal cancer
por: Sirvent, Audrey, et al.
Publicado: (2018)

Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer
por: Terai, Hideki, et al.
Publicado: (2015)

The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer
por: Elkamhawy, Ahmed, et al.
Publicado: (2021)

TWIST1 induces expression of Discoidin Domain Receptor2 (DDR2) to Promote Ovarian Cancer Metastasis
por: Grither, Whitney R., et al.
Publicado: (2018)

Functional analysis of recurrent CDC20 promoter variants in human melanoma
por: Godoy, Paula M., et al.
Publicado: (2023)

Cell-ECM interactions control DDR
por: Dickreuter, Ellen, et al.
Publicado: (2015)

Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts
por: Wasinski, Benjamin, et al.
Publicado: (2020)

Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels
por: Morikis, Vasilios A., et al.
Publicado: (2018)

MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1
por: Chou, Sung-Tau, et al.
Publicado: (2019)

Identification of Receptor Tyrosine Kinase, Discoidin Domain Receptor 1 (DDR1), as a Potential Biomarker for Serous Ovarian Cancer
por: Quan, Jinhua, et al.
Publicado: (2011)

DdrA, DdrD, and PprA: Components of UV and Mitomycin C Resistance in Deinococcus radiodurans R1
por: Selvam, Kathiresan, et al.
Publicado: (2013)

Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts
por: Angers-Loustau, Alexandre, et al.
Publicado: (1999)

DDR1 key for cancer cell escape
por: Leslie, Mitch
Publicado: (2014)

Inside the hypoxic tumour: reprogramming of the DDR and radioresistance
por: Begg, Katheryn, et al.
Publicado: (2020)

DNA Damage Response (DDR) and DNA Repair
por: Vernì, Fiammetta
Publicado: (2022)

DDR1 functions as an immune negative factor in colorectal cancer by regulating tumor‐infiltrating T cells through IL‐18
por: Duan, Xiaofan, et al.
Publicado: (2022)

Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1
por: Rudd, Meghan L, et al.
Publicado: (2014)

Prevalence of Mutations in Discoidin Domain-Containing Receptor Tyrosine Kinase 2 (DDR2) in Squamous Cell Lung Cancers in Korean Patients
por: Lee, Mi-Sook, et al.
Publicado: (2017)

Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1): A Novel Predictor for Recurrence of Hepatocellular Carcinoma After Curative Resection
por: Xu, Meng, et al.
Publicado: (2021)

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling
por: Bristol, Molly L., et al.
Publicado: (2017)

DDR1 promotes LoVo cell proliferation by regulatingenergy metabolism: Effect of DDR1 on CRC cell metabolic reprogramming
por: Xiong, Bin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_97e3j985lc66m3lt56nhqr6kd6