hGATA1 Under the Control of a μLCR/β-Globin Promoter Rescues the Erythroid but Not the Megakaryocytic Phenotype Induced by the Gata1 ( low ) Mutation in Mice

The phenotype of mice carrying the Gata1 ( low ) mutation that decreases expression of Gata1 in erythroid cells and megakaryocytes, includes anemia, thrombocytopenia, hematopoietic failure in bone marrow and development of extramedullary hematopoiesis in spleen. With age, these mice develop myelofib...

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Detalles Bibliográficos
Autores principales: Martelli, Fabrizio, Verachi, Paola, Zingariello, Maria, Mazzarini, Maria, Vannucchi, Alessandro M., Lonetti, Annalisa, Bacci, Barbara, Sarli, Giuseppe, Migliaccio, Anna Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542976/
https://www.ncbi.nlm.nih.gov/pubmed/34707640
http://dx.doi.org/10.3389/fgene.2021.720552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542976/
https://www.ncbi.nlm.nih.gov/pubmed/34707640
http://dx.doi.org/10.3389/fgene.2021.720552

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