Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in systemic lupus erythematosus

OBJECTIVES: Interferon-alpha, an important contributor to SLE pathogenesis, induces the enzyme indoleamine 2,3-dioxygenase in the kynurenine/tryptophan (KYN/TRP) pathway. This leads to a potentially neurotoxic imbalance in the KYN/TRP pathway metabolites, quinolinic acid (QA), an N-methyl D-aspartat...

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Detalles Bibliográficos
Autores principales: Anderson, Erik W, Fishbein, Joanna, Hong, Joseph, Roeser, Julien, Furie, Richard A, Aranow, Cynthia, Volpe, Bruce T, Diamond, Betty, Mackay, Meggan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Biomarker Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543639/
https://www.ncbi.nlm.nih.gov/pubmed/34686589
http://dx.doi.org/10.1136/lupus-2021-000559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543639/
https://www.ncbi.nlm.nih.gov/pubmed/34686589
http://dx.doi.org/10.1136/lupus-2021-000559

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