MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates

BACKGROUND: Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT. MYCN encodes a transcription factor that requires dimerization with MAX to activate transcription of numerous target genes. M...

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Detalles Bibliográficos
Autores principales: Jiménez Martín, Ovidio, Schlosser, Andreas, Furtwängler, Rhoikos, Wegert, Jenny, Gessler, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543820/
https://www.ncbi.nlm.nih.gov/pubmed/34689785
http://dx.doi.org/10.1186/s12935-021-02259-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543820/
https://www.ncbi.nlm.nih.gov/pubmed/34689785
http://dx.doi.org/10.1186/s12935-021-02259-2

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