Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

Late-onset Alzheimer’s disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying interventions is severely lacking. Despite exceptional efforts to understand disease progression via legacy amyloidogenic transgene mouse models,...

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Detalles Bibliográficos
Autores principales: Kotredes, Kevin P., Oblak, Adrian, Pandey, Ravi S., Lin, Peter Bor-Chian, Garceau, Dylan, Williams, Harriet, Uyar, Asli, O’Rourke, Rita, O’Rourke, Sarah, Ingraham, Cynthia, Bednarczyk, Daria, Belanger, Melisa, Cope, Zackary, Foley, Kate E., Logsdon, Benjamin A., Mangravite, Lara M., Sukoff Rizzo, Stacey J., Territo, Paul R., Carter, Gregory W., Sasner, Michael, Lamb, Bruce T., Howell, Gareth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544520/
https://www.ncbi.nlm.nih.gov/pubmed/34707490
http://dx.doi.org/10.3389/fnagi.2021.735524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544520/
https://www.ncbi.nlm.nih.gov/pubmed/34707490
http://dx.doi.org/10.3389/fnagi.2021.735524

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