Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion

We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the erythrocytic cycle with IMP-1002, an inhibitor of...

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Detalles Bibliográficos
Autores principales: Schlott, Anja C., Knuepfer, Ellen, Green, Judith L., Hobson, Philip, Borg, Aaron J., Morales-Sanfrutos, Julia, Perrin, Abigail J., Maclachlan, Catherine, Collinson, Lucy M., Snijders, Ambrosius P., Tate, Edward W., Holder, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544853/
https://www.ncbi.nlm.nih.gov/pubmed/34695132
http://dx.doi.org/10.1371/journal.pbio.3001408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544853/
https://www.ncbi.nlm.nih.gov/pubmed/34695132
http://dx.doi.org/10.1371/journal.pbio.3001408

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