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Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion
We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the erythrocytic cycle with IMP-1002, an inhibitor of...
Autores principales: | Schlott, Anja C., Knuepfer, Ellen, Green, Judith L., Hobson, Philip, Borg, Aaron J., Morales-Sanfrutos, Julia, Perrin, Abigail J., Maclachlan, Catherine, Collinson, Lucy M., Snijders, Ambrosius P., Tate, Edward W., Holder, Anthony A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544853/ https://www.ncbi.nlm.nih.gov/pubmed/34695132 http://dx.doi.org/10.1371/journal.pbio.3001408 |
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