Cargando…

Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase

The influenza virus neuraminidase (NA) is becoming a focus for novel vaccine designs. However, the epitopes of human anti-NA antibodies have been poorly defined. Using a panel of 10 anti-N2 monoclonal antibodies (MAbs) that bind the H3N2 virus A/Switzerland/9715293/2013, we generated five escape mut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kirkpatrick Roubidoux, Ericka, McMahon, Meagan, Carreño, Juan Manuel, Capuano, Christina, Jiang, Kaijun, Simon, Viviana, van Bakel, Harm, Wilson, Patrick, Krammer, Florian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544889/ https://www.ncbi.nlm.nih.gov/pubmed/33568453 http://dx.doi.org/10.1128/mSphere.00958-20

Ejemplares similares

Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies
por: Kirkpatrick Roubidoux, Ericka, et al.
Publicado: (2022)

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
por: Roubidoux, Ericka Kirkpatrick, et al.
Publicado: (2021)

Immunity induced by vaccination with recombinant influenza B virus neuraminidase protein breaks viral transmission chains in guinea pigs in an exposure intensity-dependent manner
por: McMahon, Meagan, et al.
Publicado: (2022)

Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site
por: Stadlbauer, Daniel, et al.
Publicado: (2022)

Mucosal Immunity against Neuraminidase Prevents Influenza B Virus Transmission in Guinea Pigs
por: McMahon, Meagan, et al.
Publicado: (2019)

The Human Antibody Response to the Influenza Virus Neuraminidase Following Infection or Vaccination
por: Rajendran, Madhusudan, et al.
Publicado: (2021)

H1 Hemagglutinin Priming Provides Long-Lasting Heterosubtypic Immunity against H5N1 Challenge in the Mouse Model
por: Carreño, Juan Manuel, et al.
Publicado: (2020)

Monoclonal antibodies targeting the influenza virus N6 neuraminidase
por: Strohmeier, Shirin, et al.
Publicado: (2022)

Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes
por: Wohlbold, Teddy John, et al.
Publicado: (2017)

Murine Broadly Reactive Antineuraminidase Monoclonal Antibodies Protect Mice from Recent Influenza B Virus Isolates and Partially Inhibit Virus Transmission in the Guinea Pig Model
por: Tan, Jessica, et al.
Publicado: (2022)

SARS‐CoV‐2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup
por: Stadlbauer, Daniel, et al.
Publicado: (2020)

Introduction of Cysteines in the Stalk Domain of Recombinant Influenza Virus N1 Neuraminidase Enhances Protein Stability and Immunogenicity in Mice
por: Strohmeier, Shirin, et al.
Publicado: (2021)

Animal Models Utilized for the Development of Influenza Virus Vaccines
por: Roubidoux, Ericka Kirkpatrick, et al.
Publicado: (2021)

Assessment of a quadrivalent nucleoside-modified mRNA vaccine that protects against group 2 influenza viruses
por: McMahon, Meagan, et al.
Publicado: (2022)

A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model
por: Strohmeier, Shirin, et al.
Publicado: (2021)

Detection of Velogenic Avian Paramyxoviruses in Rock Doves in New York City, New York
por: Francisco, Isabel, et al.
Publicado: (2022)

Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain
por: Altomare, Clara G., et al.
Publicado: (2022)

Study of Antibodies to Influenza Neuraminidase N2
por: Desheva, Yulia, et al.
Publicado: (2022)

Bivalent COVID-19 booster vaccines and the absence of BA.5-specific antibodies
por: Carreño, Juan Manuel, et al.
Publicado: (2023)

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
por: Pardi, Norbert, et al.
Publicado: (2018)

Broadly Protective Neuraminidase-Based Influenza Vaccines and Monoclonal Antibodies: Target Epitopes and Mechanisms of Action
por: Abbadi, Nada, et al.
Publicado: (2023)

The influenza virus hemagglutinin head evolves faster than the stalk domain
por: Kirkpatrick, Ericka, et al.
Publicado: (2018)

Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines
por: Ju, Yi, et al.
Publicado: (2022)

Broadly neutralizing antibodies target a haemagglutinin anchor epitope
por: Guthmiller, Jenna J., et al.
Publicado: (2021)

Stepwise prediction and statistical screening: B-cell epitopes on neuraminidase of human avian H(5)N(1) virus
por: Huang, Ping, et al.
Publicado: (2008)

Charged amino acid variability related to N-glyco -sylation and epitopes in A/H3N2 influenza: Hem -agglutinin and neuraminidase
por: Huang, Zhong-Zhou, et al.
Publicado: (2017)

Cross-neutralization between three mumps viruses & mapping of haemagglutinin-neuraminidase (HN) epitopes
por: Vaidya, Sunil R., et al.
Publicado: (2016)

Identification of a potential neutralizing linear epitope of hemagglutinin-neuraminidase in Newcastle disease virus
por: Jin, Zhongyuan, et al.
Publicado: (2021)

In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen
por: Wohlbold, Teddy John, et al.
Publicado: (2014)

SARS-CoV-2 Spike-Binding Antibody Longevity and Protection from Reinfection with Antigenically Similar SARS-CoV-2 Variants
por: Kubale, John, et al.
Publicado: (2022)

The Antibody Response Against Neuraminidase in Human Influenza A (H3N2) Virus Infections During 2018/2019 Flu Season: Focusing on the Epitopes of 329-N-Glycosylation and E344 in N2
por: Ge, Jing, et al.
Publicado: (2022)

SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
por: Sano, Kaori, et al.
Publicado: (2022)

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin
por: Rajendran, Madhusudan, et al.
Publicado: (2017)

Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited
por: Feng, Chiguang, et al.
Publicado: (2017)

Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers
por: Wan, Hongquan, et al.
Publicado: (2015)

Influenza Neuraminidase Subtype N1: Immunobiological Properties and Functional Assays for Specific Antibody Response
por: Changsom, Don, et al.
Publicado: (2016)

Study of immunogenicity of recombinant proteins based on hemagglutinin and neuraminidase conservative epitopes of Influenza A virus
por: Dukhovlinov, Ilya, et al.
Publicado: (2013)

In silico epitope-based vaccine design against influenza a neuraminidase protein: Computational analysis established on B- and T-cell epitope predictions
por: Almalki, Shaia, et al.
Publicado: (2022)

Identification of Hemagglutinin Mutations Caused by Neuraminidase Antibody Pressure
por: Wang, Fei, et al.
Publicado: (2021)

A universal monoclonal antibody protects against all influenza A and B viruses by targeting a highly conserved epitope in the viral neuraminidase
por: Doyle, Tracey M, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_2av71hn0had0cf7ggqtf3hddrp