Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model

Current seasonal influenza virus vaccines target regions of the hemagglutinin (HA) head domain that undergo constant antigenic change, forcing the painstaking annual reformulation of vaccines. The development of broadly protective or universal influenza virus vaccines that induce cross-reactive, pro...

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Detalles Bibliográficos
Autores principales: Roubidoux, Ericka Kirkpatrick, Carreño, Juan Manuel, McMahon, Meagan, Jiang, Kaijun, van Bakel, Harm, Wilson, Patrick, Krammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545130/
https://www.ncbi.nlm.nih.gov/pubmed/33593972
http://dx.doi.org/10.1128/mBio.03617-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545130/
https://www.ncbi.nlm.nih.gov/pubmed/33593972
http://dx.doi.org/10.1128/mBio.03617-20

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