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Interleukin-1RA Mitigates SARS-CoV-2–Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a major cause of morbidity and mortality, often as a result of acute respiratory distress syndrome. Respiratory failure is characterized by a hyperinflammatory immune response, lung vascular injury, and edema formation. The po...

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Detalles Bibliográficos
Autores principales: Xiong, Shiqin, Zhang, Lianghui, Qadir, Abdul S., Richner, Justin M., Class, Jake, Rehman, Jalees, Malik, Asrar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545251/
https://www.ncbi.nlm.nih.gov/pubmed/34496633
http://dx.doi.org/10.1161/ATVBAHA.121.316925