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Mechanisms of Hydroxyurea-Induced Cellular Senescence: An Oxidative Stress Connection?

Hydroxyurea (HU) is a water-soluble antiproliferative agent used for decades in neoplastic and nonneoplastic conditions. HU is considered an essential medicine because of its cytoreduction functions. HU is an antimetabolite that inhibits ribonucleotide reductase, which causes a depletion of the deox...

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Detalles Bibliográficos
Autores principales:	Kapor, Sunčica, Čokić, Vladan, Santibanez, Juan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545575/ https://www.ncbi.nlm.nih.gov/pubmed/34707779 http://dx.doi.org/10.1155/2021/7753857

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