Allosteric pockets and dynamic residue network hubs of falcipain 2 in mutations including those linked to artemisinin resistance

Continually emerging resistant strains of malarial parasites to current drugs present challenges. Understanding the underlying resistance mechanisms, especially those linked to allostery is, thus, highly crucial for drug design. This forms the main concern of the paper through a case study of falcip...

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Detalles Bibliográficos
Autores principales: Okeke, Chiamaka Jessica, Musyoka, Thommas Mutemi, Sheik Amamuddy, Olivier, Barozi, Victor, Tastan Bishop, Özlem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545671/
https://www.ncbi.nlm.nih.gov/pubmed/34745456
http://dx.doi.org/10.1016/j.csbj.2021.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545671/
https://www.ncbi.nlm.nih.gov/pubmed/34745456
http://dx.doi.org/10.1016/j.csbj.2021.10.011

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