Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope

HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target antibody against the Env gp120-gp41 interface, from V3-glycan...

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Detalles Bibliográficos
Autores principales: Abernathy, Morgan E., Gristick, Harry B., Vielmetter, Jost, Keeffe, Jennifer R., Gnanapragasam, Priyanthi N. P., Lee, Yu E., Escolano, Amelia, Gautam, Rajeev, Seaman, Michael S., Martin, Malcolm A., Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545924/
https://www.ncbi.nlm.nih.gov/pubmed/34697307
http://dx.doi.org/10.1038/s41541-021-00387-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545924/
https://www.ncbi.nlm.nih.gov/pubmed/34697307
http://dx.doi.org/10.1038/s41541-021-00387-4

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