HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis

SAMHD1, a human host factor found in myeloid cells which restricts HIV-1 replication. It depletes the dNTPs pool for viral cDNA syntheses, thus preventing the viral replication in the cells. The viral accessory protein, Vpx, exists only in SIVmac/HIV-2 particles. Vpx in SIVmac can induce proteosomal...

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Detalles Bibliográficos
Autores principales: Mohamed, Ahlam, Bakir, Talal, Al-Hawel, Huda, Al-Sharif, Ibtihaj, Bakheet, Razan, Kouser, Lubna, Murugaiah, Valarmathy, Al-Mozaini, Maha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545964/
https://www.ncbi.nlm.nih.gov/pubmed/34697376
http://dx.doi.org/10.1038/s41598-021-00415-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545964/
https://www.ncbi.nlm.nih.gov/pubmed/34697376
http://dx.doi.org/10.1038/s41598-021-00415-2

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