Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) allow investigations in a human cardiac model system, but disorganized mechanics and immaturity of hPSC-CMs on standard two-dimensional surfaces have been hurdles. Here, we developed a platform of micron-scale cardiac muscle bundles to co...

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Detalles Bibliográficos
Autores principales: Tsan, Yao-Chang, DePalma, Samuel J., Zhao, Yan-Ting, Capilnasiu, Adela, Wu, Yu-Wei, Elder, Brynn, Panse, Isabella, Ufford, Kathryn, Matera, Daniel L., Friedline, Sabrina, O’Leary, Thomas S., Wubshet, Nadab, Ho, Kenneth K. Y., Previs, Michael J., Nordsletten, David, Isom, Lori L., Baker, Brendon M., Liu, Allen P., Helms, Adam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546060/
https://www.ncbi.nlm.nih.gov/pubmed/34697315
http://dx.doi.org/10.1038/s41467-021-26496-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546060/
https://www.ncbi.nlm.nih.gov/pubmed/34697315
http://dx.doi.org/10.1038/s41467-021-26496-1

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