PIM1 phosphorylation of the androgen receptor and 14-3-3 ζ regulates gene transcription in prostate cancer

PIM1 is a serine/threonine kinase over-expressed in prostate cancer. We have previously shown that PIM1 phosphorylates the androgen receptor (AR), the primary therapeutic target in prostate cancer, at serine 213 (pS213), which alters expression of select AR target genes. Therefore, we sought to inve...

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Detalles Bibliográficos
Autores principales: Ruff, Sophie E., Vasilyev, Nikita, Nudler, Evgeny, Logan, Susan K., Garabedian, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546101/
https://www.ncbi.nlm.nih.gov/pubmed/34697370
http://dx.doi.org/10.1038/s42003-021-02723-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546101/
https://www.ncbi.nlm.nih.gov/pubmed/34697370
http://dx.doi.org/10.1038/s42003-021-02723-9

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