Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors

The application of induced pluripotent stem cells (iPSCs) in advanced therapies is increasing at pace, but concerns remain over their clinical safety profile. We report the first-ever application of doggybone DNA (dbDNA) vectors to generate human iPSCs. dbDNA vectors are closed-capped linear double-...

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Detalles Bibliográficos
Autores principales: Thornton, Christopher D., Fielding, Stuart, Karbowniczek, Kinga, Roig-Merino, Alicia, Burrows, Alysha E., FitzPatrick, Lorna M., Sharaireh, Aseel, Tite, John P., Mole, Sara E., Harbottle, Richard P., Caproni, Lisa J., McKay, Tristan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546411/
https://www.ncbi.nlm.nih.gov/pubmed/34729381
http://dx.doi.org/10.1016/j.omtm.2021.09.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546411/
https://www.ncbi.nlm.nih.gov/pubmed/34729381
http://dx.doi.org/10.1016/j.omtm.2021.09.018

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