USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4

Herein, we aimed to elucidate the molecular and cellular mechanism in which ubiquitin-specific protease 8 (USP8) is implicated in liver cancer progression via TRAF6-mediated signal. USP8 induces the deubiquitination of TRAF6, TAB2, TAK1, p62, and BECN1, which are pivotal roles for NF-κB activation a...

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Detalles Bibliográficos
Autores principales: Kim, Mi-Jeong, Choi, Bongkum, Kim, Ji Young, Min, Yoon, Kwon, Do Hee, Son, Juhee, Lee, Ji Su, Lee, Joo Sang, Chun, Eunyoung, Lee, Ki-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546492/
https://www.ncbi.nlm.nih.gov/pubmed/34688043
http://dx.doi.org/10.1016/j.tranon.2021.101250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546492/
https://www.ncbi.nlm.nih.gov/pubmed/34688043
http://dx.doi.org/10.1016/j.tranon.2021.101250

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