The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus

Host shutoff in influenza A virus (IAV) infection is a key process contributing to viral takeover of the cellular machinery and resulting in the downregulation of host gene expression. Analysis of nascently transcribed RNA in a cellular model that allows the functional induction of NS1 demonstrates...

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Detalles Bibliográficos
Autores principales: Nacken, Wolfgang, Schreiber, André, Masemann, Dörthe, Ludwig, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546537/
https://www.ncbi.nlm.nih.gov/pubmed/34488451
http://dx.doi.org/10.1128/mBio.02196-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546537/
https://www.ncbi.nlm.nih.gov/pubmed/34488451
http://dx.doi.org/10.1128/mBio.02196-21

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