Anaplasma phagocytophilum Hijacks Flotillin and NPC1 Complex To Acquire Intracellular Cholesterol for Proliferation, Which Can Be Inhibited with Ezetimibe

The intracellular cholesterol transport protein Niemann-Pick type C1 (NPC1) and lipid-raft protein flotillin (FLOT) are required for cholesterol uptake by the obligatory intracellular bacterium Anaplasma phagocytophilum and for infection, and each protein localizes to membrane-bound inclusions conta...

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Detalles Bibliográficos
Autores principales: Huang, Weiyan, Xiong, Qingming, Lin, Mingqun, Rikihisa, Yasuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546544/
https://www.ncbi.nlm.nih.gov/pubmed/34544283
http://dx.doi.org/10.1128/mBio.02299-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546544/
https://www.ncbi.nlm.nih.gov/pubmed/34544283
http://dx.doi.org/10.1128/mBio.02299-21

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