Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis

Hepatic failure is an important risk factor for poor outcome in septic patients. Using a chemical tagging workflow and high-resolution mass spectrometry, we demonstrate that rapid proteome remodeling of the vascular surfaces precedes hepatic damage in a murine model of Staphylococcus aureus sepsis....

Descripción completa

Detalles Bibliográficos
Autores principales: Golden, Gregory J., Toledo, Alejandro Gómez, Marki, Alex, Sorrentino, James T., Morris, Claire, Riley, Raquel J., Spliid, Charlotte, Chen, Qiongyu, Cornax, Ingrid, Lewis, Nathan E., Varki, Nissi, Le, Dzung, Malmström, Johan, Karlsson, Christofer, Ley, Klaus, Nizet, Victor, Esko, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546592/
https://www.ncbi.nlm.nih.gov/pubmed/34544271
http://dx.doi.org/10.1128/mBio.01181-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546592/
https://www.ncbi.nlm.nih.gov/pubmed/34544271
http://dx.doi.org/10.1128/mBio.01181-21

Ejemplares similares