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Huntington’s disease mouse models: unraveling the pathology caused by CAG repeat expansion
Huntington’s disease (HD) is a neurodegenerative disease that results in motor and cognitive dysfunction, leading to early death. HD is caused by an expansion of CAG repeats in the huntingtin gene (HTT). Here, we review the mouse models of HD. They have been used extensively to better understand the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Faculty Opinions Ltd
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546598/ https://www.ncbi.nlm.nih.gov/pubmed/34746930 http://dx.doi.org/10.12703/r/10-77 |