Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III

10-Deacetylbaccatin III (10-DAB) C10 acetylation is an indispensable procedure for Taxol semi-synthesis, which often requires harsh conditions. 10-Deacetylbaccatin III-10-β-O-acetyltransferase (DBAT) catalyzes the acetylation but acetyl-CoA supply remains a key limiting factor. Here we refactored th...

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Detalles Bibliográficos
Autores principales: Wang, Hao, Zhang, Bo-Yong, Gong, Ting, Chen, Tian-Jiao, Chen, Jing-Jing, Yang, Jin-Ling, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546859/
https://www.ncbi.nlm.nih.gov/pubmed/34729319
http://dx.doi.org/10.1016/j.apsb.2021.03.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546859/
https://www.ncbi.nlm.nih.gov/pubmed/34729319
http://dx.doi.org/10.1016/j.apsb.2021.03.029

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