Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218

The integrity of lysosomes is of vital importance to survival of tumor cells. We demonstrated that LW-218, a synthetic flavonoid, induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological malignancy. LW-218-induced lysosomal damage and lysosome-depende...

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Detalles Bibliográficos
Autores principales: Hu, Po, Li, Hui, Sun, Wenzhuo, Wang, Hongzheng, Yu, Xiaoxuan, Qing, Yingjie, Wang, Zhanyu, Zhu, Mengyuan, Xu, Jingyan, Guo, Qinglong, Hui, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546890/
https://www.ncbi.nlm.nih.gov/pubmed/34729308
http://dx.doi.org/10.1016/j.apsb.2021.02.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8546890/
https://www.ncbi.nlm.nih.gov/pubmed/34729308
http://dx.doi.org/10.1016/j.apsb.2021.02.004

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