Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants

Members of the Old World Arenaviruses primarily utilize α-dystroglycan (α-DAG1) as a cellular receptor for infection. Mutations within the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) reduce or abrogate the binding affinity to α-DAG1 and thus influence viral persistence, kinetics,...

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Detalles Bibliográficos
Autores principales: Volland, André, Lohmüller, Michael, Heilmann, Emmanuel, Kimpel, Janine, Herzog, Sebastian, von Laer, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547738/
https://www.ncbi.nlm.nih.gov/pubmed/34648606
http://dx.doi.org/10.1371/journal.ppat.1009996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547738/
https://www.ncbi.nlm.nih.gov/pubmed/34648606
http://dx.doi.org/10.1371/journal.ppat.1009996

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