Role of hyperpolarization-activated cyclic nucleotide-gated ion channels in neuropathic pain: a proof-of-concept study of ivabradine in patients with chronic peripheral neuropathic pain

INTRODUCTION: Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels mediate repetitive action potential firing in the heart and nervous system. The HCN2 isoform is expressed in nociceptors, and preclinical studies suggest a critical role in neuropathic pain. Ivabradine is a nonselec...

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Detalles Bibliográficos
Autores principales: Bernard Healey, Shannon A., Scholtes, Ingrid, Abrahams, Mark, McNaughton, Peter A., Menon, David K., Lee, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Neuropathic
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547924/
https://www.ncbi.nlm.nih.gov/pubmed/34712888
http://dx.doi.org/10.1097/PR9.0000000000000967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547924/
https://www.ncbi.nlm.nih.gov/pubmed/34712888
http://dx.doi.org/10.1097/PR9.0000000000000967

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