NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

Apolipoprotein E4 (ApoE4) is the most important and prevalent risk factor for late-onset Alzheimer’s disease (AD). The isoelectric point of ApoE4 matches the pH of the early endosome (EE), causing its delayed dissociation from ApoE receptors and hence impaired endolysosomal trafficking, disruption o...

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Detalles Bibliográficos
Autores principales: Pohlkamp, Theresa, Xian, Xunde, Wong, Connie H, Durakoglugil, Murat S, Werthmann, Gordon Chandler, Saido, Takaomi C, Evers, Bret M, White, Charles L, Connor, Jade, Hammer, Robert E, Herz, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547963/
https://www.ncbi.nlm.nih.gov/pubmed/34617884
http://dx.doi.org/10.7554/eLife.72034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547963/
https://www.ncbi.nlm.nih.gov/pubmed/34617884
http://dx.doi.org/10.7554/eLife.72034

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