The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation

Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in Xenopus egg extract, MTBP forms an elongated tetramer with Treslin containing two molecules of each protein. Immunodepletion and add-back experiments show that Treslin–MTBP...

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Detalles Bibliográficos
Autores principales: Volpi, Ilaria, Gillespie, Peter J., Chadha, Gaganmeet Singh, Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548084/
https://www.ncbi.nlm.nih.gov/pubmed/34699733
http://dx.doi.org/10.1098/rsob.210121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548084/
https://www.ncbi.nlm.nih.gov/pubmed/34699733
http://dx.doi.org/10.1098/rsob.210121

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